5 Day Mississippi River Cruises 2025 Schedule. Find and plan your next cruise to mississippi river with cabin price comparison, variety of departure ports and dates to choose from. A mississippi river cruise offers the rare opportunity to sail through america's heartland on the world’s #1 river cruise line.
Explore this region’s rich history with american cruise lines. Glide effortlessly along the mighty mississippi, surrounded by breathtaking panoramas of cottonwood trees.